Teodoro Bottiglieri Selected Research

Protein Phosphatase 2 (Protein Phosphatase 2A)

1/2014	Altered protein phosphatase 2A methylation and Tau phosphorylation in the young and aged brain of methylenetetrahydrofolate reductase (MTHFR) deficient mice.
3/2007	Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation.

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Teodoro Bottiglieri Research Topics

Disease

24	Hyperhomocysteinemia 01/2024 - 08/2002
12	Alzheimer Disease (Alzheimer's Disease) 09/2023 - 03/2007
10	Dementia (Dementias) 09/2023 - 06/2004
9	Major Depressive Disorder (Major Depressive Disorders) 06/2017 - 08/2004
8	Body Weight (Weight, Body) 01/2023 - 09/2002
7	Inflammation (Inflammations) 01/2024 - 03/2006
6	Parkinson Disease (Parkinson's Disease) 01/2022 - 06/2004
6	succinic semialdehyde dehydrogenase deficiency 11/2020 - 01/2003
5	Insulin Resistance 11/2023 - 11/2010
5	Ischemic Stroke 11/2023 - 01/2017
4	Fibrosis (Cirrhosis) 02/2024 - 01/2004
4	Disease Progression 06/2023 - 03/2006
4	Methylenetetrahydrofolate reductase deficiency 01/2023 - 01/2014
4	Obesity 01/2023 - 01/2016
4	Weight Gain 04/2021 - 01/2014
4	Homocystinuria 01/2021 - 04/2005
4	Cognitive Dysfunction 01/2020 - 06/2008
4	Coronary Artery Disease (Coronary Atherosclerosis) 10/2018 - 12/2016
4	Sepsis (Septicemia) 01/2018 - 07/2003
4	Neoplasms (Cancer) 10/2017 - 08/2009
4	Schizophrenia (Dementia Praecox) 06/2017 - 09/2004
4	Cardiovascular Diseases (Cardiovascular Disease) 06/2017 - 11/2004
4	Neuroblastoma 11/2015 - 05/2006
3	Non-alcoholic Fatty Liver Disease 02/2024 - 11/2010
3	Fatty Liver 02/2024 - 12/2007
3	Atherosclerosis 01/2024 - 12/2014
3	Weight Loss (Weight Reduction) 01/2024 - 12/2020
3	Stroke (Strokes) 11/2023 - 12/2019
3	Vitamin B 12 Deficiency (Vitamin B12 Deficiency) 03/2023 - 09/2005
3	Fabry Disease (Fabry's Disease) 12/2022 - 01/2017
3	Chronic Renal Insufficiency 07/2022 - 11/2016
3	Thrombosis (Thrombus) 01/2018 - 10/2006
3	Vascular Diseases (Vascular Disease) 01/2018 - 04/2004
3	Phenylketonurias (Phenylketonuria) 01/2017 - 09/2014
3	Hepatocellular Carcinoma (Hepatoma) 09/2015 - 08/2009
3	Maple Syrup Urine Disease 05/2014 - 10/2009
3	Epilepsy (Aura) 10/2012 - 01/2003
2	Ketosis 01/2024 - 07/2003
2	Congenital Abnormalities (Deformity) 06/2022 - 01/2018
2	Acute Kidney Injury (Acute Renal Failure) 01/2022 - 10/2017
2	Gliosis 11/2020 - 01/2018
2	Multiple Sclerosis 01/2020 - 11/2015
2	Pregnancy Complications 01/2018 - 01/2007
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2018 - 07/2012
2	Hypermethioninemia 12/2017 - 09/2015

Drug/Important Bio-Agent (IBA)

34	Folic Acid (Vitamin M)FDA LinkGeneric 02/2024 - 08/2002
33	HomocysteineIBA 01/2024 - 08/2002
15	Methionine (L-Methionine)FDA Link 01/2022 - 01/2004
11	S-Adenosylmethionine (Ademetionine)IBA 12/2017 - 01/2003
10	Choline (Choline Chloride)IBA 11/2023 - 01/2003
10	Vitamin B 12 (Cyanocobalamin)FDA LinkGeneric 03/2023 - 07/2003
9	Proteins (Proteins, Gene)FDA Link 11/2023 - 03/2007
8	CarbonIBA 02/2024 - 10/2013
8	Betaine (C.B.B.)FDA Link 11/2023 - 11/2010
7	Amino Acids FDA Link 01/2024 - 10/2012
7	Biomarkers (Surrogate Marker)IBA 09/2023 - 06/2011
6	Cystathionine beta-Synthase (Serine Sulfhydrase)IBA 01/2020 - 09/2002
5	LipidsIBA 01/2024 - 01/2016
5	Levodopa (L Dopa)FDA LinkGeneric 06/2023 - 06/2004
5	CystathionineIBA 01/2022 - 01/2013
5	5-methyltetrahydrofolateIBA 08/2014 - 06/2012
4	Vitamin B Complex (B Vitamins)IBA 01/2024 - 10/2008
4	Apolipoproteins E (ApoE)IBA 01/2024 - 01/2007
4	Methylenetetrahydrofolate Reductase (NADPH2) (Methylenetetrahydrofolate Reductase)IBA 01/2023 - 04/2004
4	Insulin (Novolin)FDA Link 01/2023 - 11/2004
4	AcidsIBA 04/2021 - 12/2007
4	gamma-Aminobutyric Acid (GABA)IBA 01/2020 - 01/2003
4	Amyloid (Amyloid Fibrils)IBA 01/2018 - 03/2007
4	Neurotransmitter Agents (Neurotransmitter)IBA 01/2018 - 10/2012
4	DNA (Deoxyribonucleic Acid)IBA 11/2016 - 08/2013
4	S-AdenosylhomocysteineIBA 11/2016 - 07/2005
3	ApolipoproteinsIBA 01/2024 - 12/2014
3	CholesterolIBA 09/2023 - 02/2010
3	Glucose (Dextrose)FDA LinkGeneric 01/2023 - 11/2010
3	GalactosidasesIBA 12/2022 - 01/2017
3	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 10/2018 - 01/2017
3	EnzymesIBA 10/2017 - 02/2010
3	Superoxides (Superoxide)IBA 01/2017 - 08/2004
3	Nitric Oxide Synthase (NO Synthase)IBA 01/2017 - 08/2008
3	Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)IBA 12/2012 - 12/2004
3	C-Reactive ProteinIBA 03/2010 - 11/2004
3	Fluoxetine (Prozac)FDA LinkGeneric 12/2005 - 08/2004
2	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 09/2023 - 02/2017
2	LeptinIBA 01/2023 - 12/2020
2	Triglycerides (Triacylglycerol)IBA 01/2023 - 11/2010
2	GlycosphingolipidsIBA 12/2022 - 01/2017
2	Cysteine (L-Cysteine)FDA Link 01/2022 - 01/2004
2	N,N-dimethylarginine (asymmetric dimethylarginine)IBA 01/2022 - 08/2008
2	5,11-methenyltetrahydrohomofolateIBA 04/2021 - 12/2020
2	Hormones (Hormone)IBA 01/2021 - 12/2020
2	Glutamine (L-Glutamine)FDA Link 11/2020 - 01/2019
2	Aminobutyrates (Aminobutyric Acid)IBA 01/2020 - 01/2019
2	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2020 - 01/2007
2	transcobalamin receptorIBA 01/2019 - 06/2013
2	11-dehydro-thromboxane B2IBA 10/2018 - 01/2017
2	purineIBA 01/2018 - 05/2007
2	Oxygen (Dioxygen)IBA 10/2017 - 01/2007
2	Antidepressive Agents (Antidepressants)IBA 06/2017 - 12/2004

Therapy/Procedure

8	Therapeutics 09/2018 - 02/2013
2	Diet Therapy (Therapy, Diet) 01/2018 - 10/2010